Efficacy of Hydrocotyle, Hydrastis, Petroleum and psorinum in 30CH in Imiquimod – Induced Psoriasis in Swiss Albino Mice

Abstract

A group of 30 swiss albino mice were induced with psoriasiform dermatitis by inducing imiquimod cream intradermally, then group 1 served as a control group, group 2 received methotrexate 2.5mg/kg for 3 consecutive days in a week likewise for 4 weeks and group 3 received 10drops of freshly prepared Hydrocotyle 30 for 3 consecutive days in a week likewise for 4 weeks and group 4 received 10drops of freshly prepared Hydrastis 30 for 3 consecutive days in a week likewise for 4 weeks and group 5 received 10drops of freshly prepared Petroleum 30 for 3 consecutive days in a week likewise for 4 weeks and group 6 received 10drops of freshly prepared Psorinum 30 for 3 consecutive days in a week likewise for 4 weeks. Psoriasis area severity index score was measured before after the intervention. Blood parameters and immunohistochemistry were analysed after the administration of drug. Psorinum, Petroleum, Hydrastis, Hydrocotyle, 30 is found to be effective in controlling psoriasiform dermatitis when compared with methotrexate with respect to the mentioned parameter. The study is statistically significant with a p value < 0.5